MPhil Genetics
- Country United Kingdom
- Course Duration 12 month
- Course Type Full Time
- Courses Campus On Campus
- Language Specification IELTS
- Program Level Post-Graduate
- Education Required Graduate
- Admission intake SEP
- Minimum GPA 3.3
Application Charges
| Application Fee | Tution Fee |
|---|---|
| Free | GBP 26,100 |
Application Date
| Application Start Date | Application Closing Date |
|---|---|
|
2022-12-08
|
2023-01-10
|
Program Description
Our research areas include:- genetic medicine
- developmental genetics
- neuromuscular and neurological genetics
- mitochondrial genetics
- cardiovascular genetics
Cancer genetics and genome instability
Our research includes:
- a major clinical trial for chemoprevention of colon cancer
- genetic analyses of neuroblastoma susceptibility
- research into Wilms Tumour (a childhood kidney cancer)
- studies on cell cycle regulation and genome instability.
Cardiovascular genetics and development
We use techniques of high genetic analyses. This is to identify mechanisms where genetic variability contributes to developing cardiovascular disease. We explore gene factors and how they affect the development of the heart and blood vessels.
Complex disease and quantitative genetics
We work on large scale studies on the genetic basis of common diseases with complex causes. For example, autoimmune disease, complex cardiovascular traits and renal disorders. We are developing novel statistical methods and tools for analysing this genetic data.
Developmental genetics
We study genes known or suspected to influence malformations found in newborn babies. These include genes involved in normal and abnormal development of the:
- face
- brain
- heart
- muscle
- kidney system
Gene expression and regulation in normal development and disease
We research gene expression control during development and misregulated in diseases. This looks at the roles of:
- transcription factors
- RNA binding proteins
- the signalling pathways that control these
- gene expression analysis
- primary cell culture models
- 3D visualisation and modelling
Genetics of neurological disorders
Our research includes:
- the identification of genes that in isolation can cause neurological disorders
- molecular mechanisms and treatment of neurometabolic disease
- complex genetics of common neurological disorders including Parkinson's disease and Alzheimer's disease
- the genetics of epilepsy
Kidney genetics and development
Kidney research focuses on:
- atypical haemolytic uraemic syndrome (aHUS)
- vesicoureteric reflux (VUR)
- cystic renal disease
- nephrolithiasis to study renal genetics
Mitochondrial disease
Our research includes:
- investigation of the role of mitochondria in human disease
- nuclear-mitochondrial interactions in disease
- the inheritance of mitochondrial DNA heteroplasmy
- mitochondrial function in stem cells
Neuromuscular genetics
The Neuromuscular Research Group has a series of basic research programmes. We look at the function of novel muscle proteins and their roles in pathogenesis. Recently developed translational research programmes are seeking therapeutic targets for various muscle diseases.
Stem cell biology
We research human embryonic stem (ES) cells, germline stem cells and somatic stem cells. ES cell research aims to understand:
- stem cell pluripotency
- self-renewal
- survival and epigenetic control of differentiation and development
- programmes on umbilical cord blood stem cells
- haematopoietic progenitors, and limbal stem cells
